01 Jun Norrin, Frizzled4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization
Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled4 (Fz4) receptor, Lrp5 co-receptor, or Norrin ligand cause retinal hypovascularization, but the role of Norrin/Fz4/Lrp signaling in vascular development has not been defined. ...